The Wealth Index is based on a number of indicators of affluence including average household income and average net worth, but it also includes the value of material possessions and resources. It represents the wealth of the area relative to the national level. Values above or below 100 represent above-average wealth or below-average wealth compared to the national level.
| Name | County | Wealth Index | |
|---|---|---|---|
| 1. | City of Ladue | St. Louis | 457 |
| 2. | Village of Westwood | St. Louis | 427 |
| 3. | City of Clarkson Valley | St. Louis | 410 |
| 4. | City of Town and Country | St. Louis | 395 |
| 5. | City of Huntleigh | St. Louis | 392 |
| 6. | City of Warson Woods | St. Louis | 375 |
| 7. | City of Frontenac | St. Louis | 370 |
| 8. | City of Crystal Lake Park | St. Louis | 356 |
| 9. | City of Des Peres | St. Louis | 341 |
| 10. | Village of Loch Lloyd | Cass | 325 |
| 11. | City of Weatherby Lake | Platte | 297 |
| 12. | City of Glendale | St. Louis | 289 |
| 13. | City of Wildwood | St. Louis | 272 |
| 14. | City of Weldon Spring | St. Charles | 271 |
| 15. | City of Creve Coeur | St. Louis | 262 |
| 16. | Village of Lake Tekakwitha | Jefferson | 253 |
| 17. | City of Lake Winnebago | Cass | 248 |
| 18. | LaBarque Creek Census Designated Place | Jefferson | 245 |
| 19. | City of Clayton | St. Louis | 244 |
| 20. | City of Chesterfield | St. Louis | 244 |
