The Wealth Index is based on a number of indicators of affluence including average household income and average net worth, but it also includes the value of material possessions and resources. It represents the wealth of the area relative to the national level. Values above or below 100 represent above-average wealth or below-average wealth compared to the national level.
| Name | County | Wealth Index | |
|---|---|---|---|
| 1. | City of Pine Lawn | St. Louis | 18 |
| 2. | City of Hayti Heights | Pemiscot | 22 |
| 3. | City of Hayti | Pemiscot | 23 |
| 4. | Town of Van Buren | Carter | 24 |
| 5. | City of Birch Tree | Shannon | 24 |
| 6. | City of Flordell Hills | St. Louis | 24 |
| 7. | City of Irondale | Washington | 24 |
| 8. | City of Gainesville | Ozark | 24 |
| 9. | City of Wheaton | Barry | 25 |
| 10. | Glasgow Village Census Designated Place | St. Louis | 25 |
| 11. | Village of Hillsdale | St. Louis | 25 |
| 12. | City of Country Club Hills | St. Louis | 26 |
| 13. | City of Morehouse | New Madrid | 26 |
| 14. | City of Wheatland | Hickory | 26 |
| 15. | City of Steelville | Crawford | 27 |
| 16. | City of East Prairie | Mississippi | 28 |
| 17. | City of Mansfield | Wright | 28 |
| 18. | City of Jennings | St. Louis | 28 |
| 19. | City of Lamar Heights | Barton | 28 |
| 20. | Lake Timberline Census Designated Place | St. Francois | 28 |