The Wealth Index is based on a number of indicators of affluence including average household income and average net worth, but it also includes the value of material possessions and resources. It represents the wealth of the area relative to the national level. Values above or below 100 represent above-average wealth or below-average wealth compared to the national level.
| Name | County | Wealth Index | |
|---|---|---|---|
| 1. | City of Wellston | St. Louis | 20 |
| 2. | City of Campbell | Dunklin | 23 |
| 3. | City of Hayti Heights | Pemiscot | 23 |
| 4. | Village of Hillsdale | St. Louis | 24 |
| 5. | City of Howardville | New Madrid | 25 |
| 6. | City of Mansfield | Wright | 25 |
| 7. | City of Neelyville | Butler | 25 |
| 8. | City of Pine Lawn | St. Louis | 25 |
| 9. | City of Parma | New Madrid | 26 |
| 10. | City of Winona | Shannon | 26 |
| 11. | City of Warsaw | Benton | 26 |
| 12. | City of Gainesville | Ozark | 26 |
| 13. | City of Flordell Hills | St. Louis | 26 |
| 14. | City of Alton | Oregon | 27 |
| 15. | City of Country Club Hills | St. Louis | 28 |
| 16. | City of Hayti | Pemiscot | 28 |
| 17. | City of Mountain View | Howell | 28 |
| 18. | City of Pagedale | St. Louis | 28 |
| 19. | City of Marston | New Madrid | 29 |
| 20. | City of Humansville | Polk | 29 |
